NEW!!! Many of our products can now be purchased online! Please browse the product pages for more information.
For custom quotations/inquiries, contact us through the online form or by emailing Thank you for your patience as we continue to update our website!

Tn Antigen (Serine, Fmoc, Peracetylated)

Tn Antigen (Serine, Fmoc, Peracetylated) molecular structure


SKUPack SizeAvailabilityPriceQuantity
GA121000-25MG25mgIn StockUS$300.00
GA121000-100MG100mgIn StockUS$700.00

Product Details

Name Tn Antigen (Serine, Fmoc, Peracetylated)
Product No.GA121000
Synonym(s) Fmoc-Ser(α-D-GalNAc(Ac)₃)-OH; Fmoc-Ser[GalNAc(Ac)₃-α-D]-OH; Fmoc-Ser(α-D-GalNAc)-OH, Peracetate; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-Serine; N-(9-fluorenylmethoxycarbonyl)-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-Serine
CategoryGlycoamino AcidsSerine
CAS No.120173-57-1
Molecular Weight656.63
Availability in BulkYes
Purity>95% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy.
CommentsN-Acetyl-D-Galactosamine; O-Link; Monosaccharide; Serine; Blocked; Amino Acid; Ac
ReferencesT. Ju, V.I. Otto and R.D. Cummings Angew. Chem. Int. Ed. 2011, 50, 1770 – 1791
Datasheet(s)GA121000_COA.pdf (85.359 KB)
‹ Back to Catalogue