| Name |
Tf Antigen: H-Ser(Gal(β(1-3)GalNAc)-OH
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| Product No. | GA120010 |
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| Synonym(s) |
Tf Epitope (Serine); T Antigen (Serine); H-Ser(Gal(beta(1-3)GalNAc)-OH; Galβ(1-3)GalNAc-α-1-O-Serine; Thomsen–Friedenreich Antigen
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| Category | Glycoamino AcidsSerine |
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| Formula | C17H30N2O13 |
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| Molecular Weight | 470.43 |
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| Availability | Yes |
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| Availability in Bulk | Yes |
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| Purity | >95% (NMR) |
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| Description | Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy. |
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| Comments | N-Acetyl-D-Galactosamine; O-Link; Disaccharide; Serine; Free OH; Amino Acid |
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| Datasheet(s) | GA120010_COA.pdf (82.272 KB)
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