Tn Antigen: H-Ser(α-D-GalNAc)-OH
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Product Details
| Name | Tn Antigen: H-Ser(α-D-GalNAc)-OH |
|---|---|
| Product No. | GA120000 |
| Synonym(s) | Tn Epitope (Serine); H-Ser(alpha-D-GalNAc)-OH; GalNAc-α-1-O-Serine; GalNAc-Serine; O-(2-Acetamido-2-deoxy-α-D-galactopyranosyl)-L-serine |
| Category | Glycoamino AcidsSerine |
| CAS No. | 67262-86-6 |
| Formula | C11H20N2O8 |
| Molecular Weight | 308.29 |
| Availability | Yes |
| Availability in Bulk | Yes |
| Purity | >95% (NMR) |
| Description | Tumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy. |
| Comments | N-Acetyl-D-Galactosamine; O-Link; Monosaccharide; Serine; Free OH; Amino Acid |
| Datasheet(s) | GA120000_COA.pdf (82.68 KB) |