GalNAc Ligands

Exploiting GalNAc and receptor-mediated interactions in Drug Delivery/Targeting

Use of glycobiology offers a means of addressing the specific challenge of delivering and targeting difficult therapeutic molecules such as proteins, antibodies and oligonucleotides. The idea that carbohydrates, including GalNAc, mediate receptor binding, cell targeting and cellular uptake of molecules has been been known for decades.

GalNAc, in particular, has been adopted and successfully applied as a targeting ligand in antisense oligonucleotides and siRNA. GalNAc specifically guides oligonucleotide payloads into liver cells via asialoglyoprotein receptors (ASGPR) on hepatocytes.

Cell-specific delivery of oligonucleotide therapeutics or virtually any therapeutic agent via GalNAc ligand targeting offers incredible potential.