Account:
Register
Login
0
News:
Sussex Research Laboratories Inc. Welcomes
Dr. Nycholat
as New
CSO
and
Director
of U.S. Subsidiary in San Diego -
Read more...
0
View all products
https://www.sussex-research.com/products
Products
Products
Sussex Research has developed a modern glyco product portfolio designed to help researchers explore glycobiology for glycotherapeutic applications. We translate complex carbohydrate chemistries into unique, leading-edge products designed to help researchers explore and exploit glycobiology with a view to advancing the field and creating new biomedical applications that advance human health.
Biotinylated Ligands
Biotinylated Ligands
Biotinylated glycans are emerging as a valuable class of carbohydrate or glycoconjugate probes that allow exploitation of the strong affinity of avidin and streptavidin for biotin, a feature vastly utilized across molecular biology for decades. Techniques for the study of protein–carbohydrate interactions are of great interest in glycobiology and to this day, Sussex Research Laboratories Inc. has been developing biotinylated saccharides to advance research in the field.
Carbohydrate Ligands
Carbohydrate Ligands
Sussex Research Laboratories Inc. is the leading commercial source of synthetic, well-defined carbohydrate ligands. These are multi-purpose, functionalized products that enable researchers to modify virtually any molecule, large or small, with carbohydrates via simple discrete, monodisperse polyethylene glycol (PEG) or alkyl linker/spacer systems. In contrast to traditional alkyl linker/spacers, PEG linker/spacers are water soluble and amphiphilic which reduces linker hydrophobic interactions with macromolecules and surfaces.
GalNAc Ligands
GalNAc Ligands
Sussex Research Laboratories Inc. has developed an extensive selection of functionalized GalNAc ligands with various alkyl and/or polyethylene glycol (PEG) linker/spacer systems. These enable facile introduction of GalNAc-based recognition elements onto a variety of molecules including but not limited to small molecules, surfaces, nanoparticles, peptides, proteins, antibodies, lipids and oligonucleotides.
Glucuronide Metabolites
Glucuronide Metabolites
In nature, glucuronidation is one of the main phase 2 metabolic pathways by which an organism transforms a small molecule drug or xenobiotic into a more water-soluble substance which may be responsible for a drug’s therapeutic affect but certainly enable its detoxification and further excretion. Glucuronides are formed enzymatically by the UDP-Glucuronosyltransferases which have been reported active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and the brain.
Glycoamino Acids
Glycoamino Acids
Sussex Research Laboratories Inc. has provided researchers with the most extensive selection of commercially available, high purity glycosylated amino acids (glycoamino acids). In nature, protein glycosylation, forming glycosylated proteins or glycopeptides, is a fundamental posttranslational modification process that controls protein shape, half-life and essential biological pathways ranging from protein trafficking to cell adhesion. Glycoamino acids are the basic sites of protein glycosylation, most commonly occurring at serine and threonine in the case of O-linked proteins, and at asparagine (Asn) in the case of N-linked glycoproteins.
Glycopeptides
Glycopeptides
Glycopeptides offer a unique frontier for research & development. The critical role of glycan elements on cell surface proteins and those bound to circulatory proteins is well recognized. Carbohydrates on proteins mediate a host of biological events including cell adhesion, immune system function, fertilization, cellular targeting as well as protein transport, stabilization, and half-life. Thus, the use of synthetic glycoproteins or their fragments (glycopeptides) as experimental probes for basic research and biomedical applications is growing rapidly.
Mono, Oligo & Polysaccharides
Mono, Oligo & Polysaccharides
Sussex Research Laboratories Inc. prides itself on its ability to synthesize, purify and fully characterize complex carbohydrate systems such as oligosaccharides. From blood group to GAG oligosaccharides, we are experienced in virtually all aspects of oligosaccharide synthesis. The company has an excellent infrastructure including in-house high field NMR and mass spectrometry facilities for structural validation. We use chemical, enzymatic and chemoenzymatic approaches to synthesize our oligosaccharides.
Multivalent GalNAc Ligands
Tools, Click Chemistry & Probes
Tools, Click Chemistry & Probes
As glycan features are determined on lipids and proteins within complex biological systems, it’s important to translate these findings into useful products that help advance the science in practical ways or offer new therapeutic targets to treat diseases, effect delivery of therapeutic payloads or create new biomarkers to diagnose and prognose diseases.
Reference Standards
Reference Standards
Sussex Research Laboratories Inc. synthesizes reference standards which are routinely used for quantitation and qualification of API (Active Pharmaceutical Ingredient), Metabolites and NCE’s (New Chemical Entity), as well as for Internal Standards in bioanalytical methods. These include stable isotopes (deuterated, 13C and 15N), glucuronides, metabolites & impurities.
Vitamin Standards
Vitamin Standards
These synthetic stable isotope-labelled vitamin D2, D3, E and cholesterol products, along with their hydroxy metabolites, are of the highest quality and used by researchers worldwide. These stable isotope-labelled standards are optimal for use as gold standard analytical standards and as such are trusted in the analytical protocols of global nutrition companies and bioanalytical contract research organizations on five continents.
Learn More
https://www.sussex-research.com/learn/
Learn
About Us
About Us
Sussex Research Laboratories Inc. has been diligently serving the research & development community for over 25 years and is the leading specialist in the design and synthesis of carbohydrate-based molecules for the advancement of human health.
Our Teams
Our Teams
Learn about the exceptionally qualified individuals who set Sussex Research Laboratories Inc. apart from the rest.
News
News
Explore recent news and collaborations featuring Sussex Research Laboratories Inc.
Careers
Careers
Join our dedicated team of chemists who are passionate about carbohydrate synthesis and synthetic challenges.
Request a Quotation
https://www.sussex-research.com/contact-us/?dfltForm=raqform
Services
Services
Sussex Research Laboratories Inc. has been working in the carbohydrate field for over two decades and have applied our synthetic strategies to seemingly countless problems. We have enabled application of complex carbohydrate systems for drug discovery, drug delivery, drug targeting, carbohydrate-based vaccine development, immunotherapy, therapeutic enhancement and diagnostic/bio-analytical assay development.
Custom Synthesis
Custom Synthesis
As an established global leader in carbohydrate synthesis, we strive to develop synthetic methods that are scalable, cost-effective and enabling. We prepare a wide variety of custom glycopeptides, oligosaccharides, modified carbohydrates and many other glycosystems.
Contract Research & Development
Contract Research & Development
We are known worldwide for our contract R&D capabilities which utilize our core expertise in carbohydrate synthesis and method development.
Early Stage Drug Development
Early Stage Drug Development
We have been active in the field for many years in early stage drug development specializing in GalNAc for drug targeting, polysaccharide chemistry for vaccine development and glycans for cancer research.
Antibody Drug Conjugate (ADC)
Antibody Drug Conjugate (ADC)
Therapeutic antibodies have become the predominant class of new drugs developed in recent years. Whether it is the antigen required to screen antibodies or to produce an antibody, we have the synthetic tools to produce carbohydrate antigens and their respective carrier protein conjugates.
Analytical Services
Analytical Services
We offer analytical and bioanalytical services on a fee-for-service basis – from glycoanalysis in support of structure characterization to small molecule characterization and bioanalytical analysis in support of drug discovery and research programs.
Send a Message
https://sussex-research.com/contact-us/
Contact
Account
Pay
0
Product Category
Biotinylated Ligands
Carbohydrate Ligands
GalNAc Ligands
Glucuronide Metabolites
Glycoamino Acids
Glycopeptides
Mono, Oligo & Polysaccharides
Multivalent GalNAc Ligands
Reference Standards
Tools, Click Chemistry & Probes
Uncategorized
Vitamin Standards
Sort by
Default (by Product #)
Alphabetically
Searched for:
gu119001
In Stock
Product #
: GU119001
CAS #
: 879396-70-0
Silodosin-O-β-D-Glucuronide
Other Names
: Silodosin Glucuronide
Add to quote
This product is already in your quote request list.
Browse the list
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept All”, you consent to the use of ALL the cookies. However, you may visit "Settings" to provide a controlled consent.
Settings
Accept All
Manage consent
Close
Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
Cookie
Duration
Description
cookielawinfo-checkbox-analytics
11 months
This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional
11 months
The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary
11 months
This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others
11 months
This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance
11 months
This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy
11 months
The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.