| Description | Tumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy. |
| Keywords | Tn Antigen: H-Thr(alpha-D-GalNAc)-OH, N-Acetyl-D-Galactosamine, O-Link, Monosaccharide, Threonine, Free OH, Amino Acid, , Tn Epitope (Threonine), GalNAc-alpha-1-O-Threonine, GalNAc-Threonine, O-(2-Acetamido-2-deoxy-alpha-D-galactopyranosyl)-L-threonine, C12H22N2O8, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids |