| Other Names | Tn Epitope (Threonine), Tn Antigen (Threonine, Fmoc, Peracetylated), Fmoc-Thr(α-D-GalNAc(Ac)3)-OH, Fmoc-Thr(alpha-D-GalNAc(Ac)3)-OH, N-α-Fmoc-O-β-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-threonine, N-(9-fluorenylmethoxycarbonyl)-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-threonine |
| CAS # | 116783-35-8 |
| Formula | C33H38N2O13 |
| Molecular Weight | 670.66 |
| Purity | >95% (HPLC) |
| Description | Tumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy. |
| Keywords | Tn Antigen: Fmoc-Thr(GalNAc(Ac)3-alpha-D)-OH, N-Acetyl-D-Galactosamine, O-Link, Monosaccharide, Threonine, Blocked, Amino Acid, Ac, Tn Epitope (Threonine), Tn Antigen (Threonine, Fmoc, Peracetylated), Fmoc-Thr(alpha-D-GalNAc(Ac)3)-OH, Fmoc-Thr(alpha-D-GalNAc(Ac)3)-OH, N-alpha-Fmoc-O-beta-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-galactopyranosyl)-L-threonine, N-(9-fluorenylmethoxycarbonyl)-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-galactopyranosyl)-L-threonine, C33H38N2O13, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids |
| Shipping Requirement | Ambient |
| Safety Data Sheets | Email info@sussex-research.com |
| Datasheets | |