Category: Tn Antigen

Fmoc-Ser(GalNAc(Ac)₃-α-D)-OH

Fmoc-Ser(GalNAc(Ac)3-α-D)-OH is directly relevant to the study and synthesis of molecules related to Tumor-Associated Carbohydrate Antigens (TACAs) and Tn Antigen, which are crucial in cancer research and immunotherapy. TACAs are carbohydrate structures found on the surface of cancer cells and are known to play a role in tumor growth, metastasis, and immune evasion. The Tn Antigen, a specific type of TACA, consists of a single N-acetylgalactosamine (GalNAc) molecule attached to the oxygen atom of a serine or threonine residue in the protein backbone.

Fmoc-Ser(GalNAc(Ac)3-α-D)-OH allows for the synthesis of glycopeptides that mimic the structure of Tn Antigen. This is significant because Tn Antigen is overexpressed in various types of cancer and is involved in the malignant transformation of cells, making it a target for cancer vaccines and diagnostic markers. By synthesizing glycopeptides that closely resemble natural Tn Antigens, researchers can develop better tools to study the role of these antigens in cancer and to create more effective cancer immunotherapies. These synthetic glycopeptides can be used to generate antibodies that specifically recognize Tn Antigens, leading to improved cancer diagnostics and targeted therapies that harness the immune system to fight cancer.

Other Names: Tn Epitope (Serine); Tn Antigen (Serine, Fmoc, Peracetylated); Fmoc-L-Ser(GalNAc(Ac)₃-α-D)-OH; Fmoc-Ser(α-D-GalNAc(Ac)₃)-OH; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-Serine; N-(9-fluorenylmethoxycarbonyl)-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-Serine; Fmoc-Ser(α-D-GalNAc(Ac)3)-OH; Fmoc-Ser[GalNAc(Ac)3-α-D]-OH; Fmoc-Ser(α-D-GalNAc)-OH, Peracetate

References: T. Ju, V.I. Otto and R.D. Cummings Angew. Chem. Int. Ed. 2011, 50, 1770 – 1791