Tf Antigen: H-Thr(Gal(β(1-3)GalNAc)-OH

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Product #: GA130010

Tf Antigen: H-Thr(Gal(β(1-3)GalNAc)-OH

Product Details

Other Names Tf Epitope (Threonine), T Antigen (Threonine), Galβ(1-3)GalNAc-α-1-O-Threonine, Thomsen–Friedenreich Antigen
CAS #60280-58-2
FormulaC18H32N2O13
Molecular Weight484.46
Purity>95% (NMR)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.
Keywords Tf Antigen: H-Thr(Gal(beta(1-3)GalNAc)-OH, N-Acetyl-D-Galactosamine, O-Link, Disaccharide, Threonine, Free OH, Amino Acid, , Tf Epitope (Threonine), T Antigen (Threonine), Galbeta(1-3)GalNAc-alpha-1-O-Threonine, Thomsen–Friedenreich Antigen, C18H32N2O13, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
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