Pack SizePrice (USD)AvailabilityQuantity
1mg$475.00In Stock
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2mg$750.00In Stock
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5mg$1,400.00In Stock
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10mg$2,250.00In Stock
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Tf Antigen: H-Ser(Gal(β(1-3)GalNAc)-OH


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SKU: 3914d70755f2 Categories: ,

Product #: GA120010

Tf Antigen: H-Ser(Gal(β(1-3)GalNAc)-OH

Product Details

Other Names Tf Epitope (Serine), T Antigen (Serine), H-Ser(Gal(beta(1-3)GalNAc)-OH, Galβ(1-3)GalNAc-α-1-O-Serine, Thomsen–Friedenreich Antigen
Molecular Weight470.43
Purity>95% (NMR)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.
Keywords Tf Antigen: H-Ser(Gal(beta(1-3)GalNAc)-OH, N-Acetyl-D-Galactosamine, O-Link, Disaccharide, Serine, Free OH, Amino Acid, Tf Epitope (Serine), T Antigen (Serine), H-Ser(Gal(beta(1-3)GalNAc)-OH, Galbeta(1-3)GalNAc-alpha-1-O-Serine, Thomsen–Friedenreich Antigen, C17H30N2O13, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
Shipping RequirementAmbient
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