| Other Names | Tf Epitope (Serine), T Antigen (Serine), H-Ser(Gal(beta(1-3)GalNAc)-OH, Galβ(1-3)GalNAc-α-1-O-Serine, Thomsen–Friedenreich Antigen |
| Formula | C17H30N2O13 |
| Molecular Weight | 470.43 |
| Purity | >95% (NMR) |
| Description | Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy. |
| Keywords | Tf Antigen: H-Ser(Gal(beta(1-3)GalNAc)-OH, N-Acetyl-D-Galactosamine, O-Link, Disaccharide, Serine, Free OH, Amino Acid, Tf Epitope (Serine), T Antigen (Serine), H-Ser(Gal(beta(1-3)GalNAc)-OH, Galbeta(1-3)GalNAc-alpha-1-O-Serine, Thomsen–Friedenreich Antigen, C17H30N2O13, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids |
| Shipping Requirement | Ambient |
| Safety Data Sheets | Email info@sussex-research.com |
| Datasheets | |