Pack SizePrice (USD)AvailabilityQuantity
25mg$750.00In Stock
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100mg$1,985.00In Stock
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250mg$4,000.00In Stock
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500mg$6,450.00In Stock
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Tf Antigen: Fmoc-Thr(Galβ(1-3)GalNAc)-OH (Peracetate)


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SKU: d125042d42f7 Categories: ,

Product #: GA131010

Tf Antigen: Fmoc-Thr(Galβ(1-3)GalNAc)-OH (Peracetate)

Product Details

Other Names Tf Epitope (Threonine), T Antigen (Threonine,Fmoc, Peracetylated), Thomsen–Friedenreich Antigen, Core 1 Glycan (Threonine), Fmoc-Thr[β-D-Gal(Ac)4-(1-3)-α-D-GalNAc(Ac)2]-OH, O-{2-acetamido-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-4,6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl}-N α-(fluoren-9-yl-methoxycarbonyl)-L-Threonine
CAS #125760-33-0
Molecular Weight958.91
Purity>95% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1 glycan) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.
Keywords Tf Antigen: Fmoc-Thr(Galbeta(1-3)GalNAc)-OH (Peracetate), N-Acetyl-D-Galactosamine, O-Link, Disaccharide, Threonine, Blocked, Amino Acid, Ac, Tf Epitope (Threonine), T Antigen (Threonine,Fmoc, Peracetylated), Thomsen–Friedenreich Antigen, Core 1 Glycan (Threonine), Fmoc-Thr[beta-D-Gal(Ac)4-(1-3)-alpha-D-GalNAc(Ac)2]-OH, O-{2-acetamido-3-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-4,6-di-O-acetyl-2-deoxy-alpha-D-galactopyranosyl}-N alpha-(fluoren-9-yl-methoxycarbonyl)-L-Threonine, C45H54N2O21, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
Shipping RequirementAmbient
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