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TF Antigen: Fmoc-Thr(Galβ(1-3)GalNAc)-OH (Peracetate)


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SKU: d9b3d268993c Categories: ,

Product #: GA131010

TF Antigen: Fmoc-Thr(Galβ(1-3)GalNAc)-OH (Peracetate)

Product Details

Other Names TF Epitope (Threonine), T Antigen (Threonine,Fmoc, Peracetylated), Thomsen–Friedenreich Antigen, Core 1 Glycan (Threonine), Fmoc-Thr[β-D-Gal(Ac)4-(1-3)-α-D-GalNAc(Ac)2]-OH, O-{2-acetamido-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-4,6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl}-N α-(fluoren-9-yl-methoxycarbonyl)-L-Threonine, Fmoc-Thr(α-Gal β(1-3)GalNAc)-OH, Peracetate
CAS # 125760-33-0
Formula C45H54N2O21
Molecular Weight 958.91
Purity >95% (HPLC)
Description Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1 glycan) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.
Keywords TF Antigen: Fmoc-Thr(Galbeta(1-3)GalNAc)-OH (Peracetate), N-Acetyl-D-Galactosamine, O-Link, Disaccharide, Threonine, Blocked, Amino Acid, Ac, TF Epitope (Threonine), T Antigen (Threonine,Fmoc, Peracetylated), Thomsen–Friedenreich Antigen, Core 1 Glycan (Threonine), Fmoc-Thr[beta-D-Gal(Ac)4-(1-3)-alpha-D-GalNAc(Ac)2]-OH, O-{2-acetamido-3-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-4,6-di-O-acetyl-2-deoxy-alpha-D-galactopyranosyl}-N alpha-(fluoren-9-yl-methoxycarbonyl)-L-Threonine, C45H54N2O21, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
References F.J. Irazoqui et al., Immunology and Cell Biology 2005, 83, 405–412
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