| Other Names | Tf Antigen (Serine, NHAc, Methyl Ester), T Antigen (Serine, blocked amino acid), Tf Epitope (Serine), T Antigen (Serine), Galβ(1-3)GalNAc-α-1-O-Serine, Thomsen–Friedenreich Antigen |
| Description | Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy. |
| Keywords | Tf Antigen: Ac-Ser(alpha-Galbeta(1-3)GalNAc)-OCH3, N-Acetyl-D-Galactosamine, O-Link, Disaccharide, Serine, Blocked, Amino Acid, Ac, Me, Tf Antigen (Serine, NHAc, Methyl Ester), T Antigen (Serine, blocked amino acid), Tf Epitope (Serine), T Antigen (Serine), Galbeta(1-3)GalNAc-alpha-1-O-Serine, Thomsen–Friedenreich Antigen, C2H34N2O14, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids |