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STF Antigen: Fmoc-Thr(Neu5Acα(2-3)Galβ(1-3)GalNAc)-OH (Peracetate, Methyl Ester)

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Product #: GA131020

STF Antigen: Fmoc-Thr(Neu5Acα(2-3)Galβ(1-3)GalNAc)-OH (Peracetate, Methyl Ester)

Product Details

Other Names STF Epitope (Threonine), STF Antigen (Threonine), ST Antigen, Sialyl-T Antigen, Fmoc-Thr(α-L-Neu5Ac(Ac)4-(2-3)-β-D-Gal(Ac)3-(1-3)-α-D-GalNAc(Ac)2)-OH, ST Antigen (Fmoc-Threonine, Peracetate, Methyl ester), α(2,3)Sialyl TF Antigen (Fmoc-Threonine, Peracetate, Methyl ester), Neu5Acα(2,3)Galβ(1,3)GalNAcα–Thr (Fmoc, Peracetate, Methyl ester), Nα-(Fluoren-9-ylmethoxycarbonyl)-O-[(methyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)-(2→3)-2,4,6-tri-O-acetyl-β-D-galactopyranosyl-(1→3)-2-N-acetamido-2-deoxy-4,6-di-O-acetyl-α-D-]-L-threonine
CAS # 125760-33-0
Formula C63H79N3O32
Molecular Weight 1390.3
Purity >95% (HPLC)
Description Tumor-Associated Carbohydrate Antigen (TACA). STF-antigen (also ST) is a sialylated form of the truncated O-glycosylated core determinant TF (also T) with structure: Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr. STF results from an early sialylation of the TF antigen due to overexpression of the enzyme α2,3sialylT and/or disruption of further glycan elongation processes. STF is negligibly expressed in healthy tissues but overexpressed in human carcinomas . As such, STF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STF a prime target for cancer immunotherapy.
Keywords STF Antigen: Fmoc-Thr(Neu5Acalpha(2-3)Galbeta(1-3)GalNAc)-OH (Peracetate, Methyl Ester), N-Acetyl-D-Galactosamine, O-Link, Trisaccharide, Threonine, Blocked, Amino Acid, Ac, Me, STF Epitope (Threonine), STF Antigen (Threonine), ST Antigen, Sialyl-T Antigen, Fmoc-Thr(alpha-L-Neu5Ac(Ac)4-(2-3)-beta-D-Gal(Ac)3-(1-3)-alpha-D-GalNAc(Ac)2)-OH, C63H79N3O32, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
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