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STf Antigen: Fmoc-Ser(Neu5Acα(2-3)Galβ(1-3)GalNAc)-OH (Peracetate, Benzyl Ester)

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Product #: GA121020

STf Antigen: Fmoc-Ser(Neu5Acα(2-3)Galβ(1-3)GalNAc)-OH (Peracetate, Benzyl Ester)

Product Details

Other Names STf Epitope (Serine), STf Antigen (Serine), ST Antigen, Sialyl-T Antigen, Fmoc-L-Ser(Neu5Acα(2-3)Galβ(1-3)GalNAc)-OH (Peracetate, Benzyl Ester), Fmoc-Ser(α-L-Neu5Ac(Ac)4-(2-3)-β-D-Gal(Ac)3-(1-3)-α-D-GalNAc(Ac)2)-OH
FormulaC62H77N3O32
Molecular Weight1376.28
Purity>90% (HPLC)
DescriptionTumor-Associated Carbohydrate Antigen (TACA). STF-antigen (also ST) is a sialylated form of the truncated O-glycosylated core determinant TF (also T) with structure: Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr. STF results from an early sialylation of the TF antigen due to overexpression of the enzyme α2,3sialylT and/or disruption of further glycan elongation processes. STF is negligibly expressed in healthy tissues but overexpressed in human carcinomas . As such, STF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STF a prime target for cancer immunotherapy.
Keywords STf Antigen: Fmoc-Ser(Neu5Acalpha(2-3)Galbeta(1-3)GalNAc)-OH (Peracetate, Benzyl Ester), N-Acetyl-D-Galactosamine, O-Link, Trisaccharide, Serine, Blocked, Amino Acid, Ac, Me, STf Epitope (Serine), STf Antigen (Serine), ST Antigen, Sialyl-T Antigen, Fmoc-L-Ser(Neu5Acalpha(2-3)Galbeta(1-3)GalNAc)-OH (Peracetate, Benzyl Ester), Fmoc-Ser(alpha-L-Neu5Ac(Ac)4-(2-3)-beta-D-Gal(Ac)3-(1-3)-alpha-D-GalNAc(Ac)2)-OH, C62H77N3O32, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
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