Pack Size Price (USD) Availability Quantity
0.5mg$375.00In Stock
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1mg$575.00In Stock
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2mg$975.00In Stock
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SKU: fa709fb26229 Categories: ,

Product #: GP100050


Product Details

where S* = Ser* = GalNAcα-O-Ser
Other Names mmunoglobulin heavy constant alpha 1 (IGHA1), Synthetic Hinge region (Tn) glycopeptide (HP)
UniProt ID P01876
Formula C179H275N49O60S3
Molecular Weight 4169.59
Purity >90% (HPLC)
Description Immunoglobulin A (IgA1) tryptic peptide:synthetic Hinge Region peptide fragment (His89-Arg126; UniProt position 89-126, aa length 38) with glycosylation (α-GalNAc) at Ser111(Tn antigen). The C-terminus is an amide. Immunoglobulin A (IgA) is the most abundantly produced antibody with an important role in mucosal immunity. Occurring in two structurally and functionally distinctive subclasses (IgA1 and IgA2), aberrant O-glycosylation in the hinge region of IgA1 plays a key role in the pathogenesis of IgA nephropathy (IgAN).
Keywords IgA1(89-126)-Tn(111), N-Acetyl-D-Galactosamine, O-Linked, Mono-Glycosylated, L-Serine, C-Terminus-Amide, Tn-Glycopeptide, Immunoglobulin heavy constant alpha 1 (IGHA1), Synthetic Hinge region (Tn) glycopeptide (HP), C179H275N49O60S3
References V. Franc et al., J Proteomics 2013, 92, 299–312.
Shipping Requirement Dry Ice
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