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0.5mg$375.00In Stock
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IgA1(89-126)-Tn(111)

$375.00 – $975.00

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SKU: fa709fb26229 Categories: ,

Product #: GP100050

IgA1(89-126)-Tn(111)

Product Details

Sequence HYTNPSQDVTVPCPVPSTPPTPS*PSTPPTPSPSCCHPR-NH2;
H-His-Tyr-Thr-Asn-Pro-Ser--Gly-ln-Asp-Val-Thr-Val-Pro-Cys-Pro-Val-Pro-Ser-Thr-Pro-Pro-Thr-Pro-Ser*-Pro-Ser-Thr-Pro-Pro-Thr-Pro-Ser-Pro-Ser-Cys-Cys-His-Pro-Arg-NH2;
where S* = Ser* = GalNAcα-O-Ser
Other Names mmunoglobulin heavy constant alpha 1 (IGHA1), Synthetic Hinge region (Tn) glycopeptide (HP)
UniProt ID P01876
Formula C179H275N49O60S3
Molecular Weight 4169.59
Purity >90% (HPLC)
Description Immunoglobulin A (IgA1) tryptic peptide:synthetic Hinge Region peptide fragment (His89-Arg126; UniProt position 89-126, aa length 38) with glycosylation (α-GalNAc) at Ser111(Tn antigen). The C-terminus is an amide. Immunoglobulin A (IgA) is the most abundantly produced antibody with an important role in mucosal immunity. Occurring in two structurally and functionally distinctive subclasses (IgA1 and IgA2), aberrant O-glycosylation in the hinge region of IgA1 plays a key role in the pathogenesis of IgA nephropathy (IgAN).
Keywords IgA1(89-126)-Tn(111), N-Acetyl-D-Galactosamine, O-Linked, Mono-Glycosylated, L-Serine, C-Terminus-Amide, Tn-Glycopeptide, Immunoglobulin heavy constant alpha 1 (IGHA1), Synthetic Hinge region (Tn) glycopeptide (HP), C179H275N49O60S3
Shipping Requirement Dry Ice
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