Core Glycan: Core 3 glycan is one of 4 core structures of O-GalNAc glycans of mucins. Core 3 β1,3-N-acetylglucosaminyltransferase (C3GnT) controls the biosynthesis of core 3 O-glycans and is expressed mainly in the intestine and salivary glands. Core 3 disaccharide can be further extended to form larger glycans. Reduced core3 synthase activity has been detected in malignant tumor cells and it has been reported that increased core3 O-glycan structure negatively regulates tumorigenesis by regulating the function of α2β1 integrin in prostate cancer.
Other Names:
Core 3 O-Glycan on Threonine;
Fmoc-Thr(β-D-GlcNAc(Ac)3-(1-3)-α-D-GalNAc(Ac)2)-OH
References:
Lee S. H., et al., J. Biol. Chem. 2009, 284, 17157–17169.
