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Biotin-PDPN(74-85-Gly-Lys)-Tn(77) Mouse

$450.00 – $600.00

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SKU: 3542d7a675bd Categories: ,

Product #: GP100130

Biotin-PDPN(74-85-Gly-Lys)-Tn(77) Mouse

Product Details

Sequence ERGT*KPPLEELS-GK(biotinyl)-NH2;
H-Glu-Arg-Gly-Thr*-Lys-Pro-Pro-Leu-Glu-Glu-Leu-Ser-Gly-Lys(biotin)NH2;
where T* = Thr* = GalNAcα-O-Thr
Other Names Synthetic podoplain glycopeptide, PDPN(Tn) glycopeptide
UniProt ID Q62011
Formula C84H141N23O29S
Molecular Weight 1969.2
Purity >90% (HPLC)
Description PDPN (UniProt ID Q62011) synthetic Glyco-dodecapeptide epitope (Glu74-Ser85-Gly-Lys) that is present within the extracellular domain of the glycoprotein podoplanin. The glycopeptide fragment has tumor-associated cancer antigen Tn at Thr77. Biotin was appended on the ε-amine of the C-terminal lysine. The posttranslational GalNAc modification is expressed by an aggressive fibrosarcoma, Ag104A, and is bound by Anti-Tn Antigen [237mAb].
Keywords Biotin-PDPN(74-85-Gly-Lys)-Tn(77) Mouse, N-Acetyl-D-Galactosamine, O-Linked, Mono-Glycosylated, L-Threonine, Biotinylated, C-Terminus-Amide, Tn-Glycopeptide, Synthetic podoplain glycopeptide, PDPN(Tn) glycopeptide, C84H141N23O29S
References Cory L. Brooks, et al., Proc Natl Acad Sci USA. 2010; 107: 10056–10061.
Shipping Requirement Dry Ice
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