Glucuronides are uronic acid-containing metabolites formed in vivo when a glucuronic acid is bound to a drug or xenobiotic. In nature, glucuronidation is one of the main phase 2 metabolic pathways by which an organism transforms a small molecule drug or xenobiotic into a more water-soluble substance which may be responsible for a drug’s therapeutic affect but certainly enables its detoxification and further excretion. In biological systems, glucuronides are formed enzymatically by the UDP-Glucuronosyltransferases which have been reported active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and the brain.
We synthesize glucuronides via synthetic chemistry, and structures are confirmed via Proton NMR and Mass Spectrometry. Purity is determined by HPLC.
View our glucuronides listing below. If you’re unable to find what you’re looking for, please request for a custom synthesis.