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Sussex Research Laboratories Inc. Appoints
Dr. Corwin Nycholat
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Sussex Research has developed a modern glyco product portfolio designed to help researchers explore glycobiology for glycotherapeutic applications. We translate complex carbohydrate chemistries into unique, leading-edge products designed to help researchers explore and exploit glycobiology with a view to advancing the field and creating new biomedical applications that advance human health.
Biotinylated Ligands
Biotinylated Ligands
Biotinylated glycans are emerging as a valuable class of carbohydrate or glycoconjugate probes that allow exploitation of the strong affinity of avidin and streptavidin for biotin, a feature vastly utilized across molecular biology for decades. Techniques for the study of protein–carbohydrate interactions are of great interest in glycobiology and to this day, Sussex Research Laboratories Inc. has been developing biotinylated saccharides to advance research in the field.
Carbohydrate Ligands
Carbohydrate Ligands
Sussex Research Laboratories Inc. is the leading commercial source of synthetic, well-defined carbohydrate ligands. These are multi-purpose, functionalized products that enable researchers to modify virtually any molecule, large or small, with carbohydrates via simple discrete, monodisperse polyethylene glycol (PEG) or alkyl linker/spacer systems. In contrast to traditional alkyl linker/spacers, PEG linker/spacers are water soluble and amphiphilic which reduces linker hydrophobic interactions with macromolecules and surfaces.
GalNAc Ligands
GalNAc Ligands
Sussex Research Laboratories Inc. has developed an extensive selection of functionalized GalNAc ligands with various alkyl and/or polyethylene glycol (PEG) linker/spacer systems. These enable facile introduction of GalNAc-based recognition elements onto a variety of molecules including but not limited to small molecules, surfaces, nanoparticles, peptides, proteins, antibodies, lipids and oligonucleotides.
Glucuronide Metabolites
Glucuronide Metabolites
In nature, glucuronidation is one of the main phase 2 metabolic pathways by which an organism transforms a small molecule drug or xenobiotic into a more water-soluble substance which may be responsible for a drug’s therapeutic affect but certainly enable its detoxification and further excretion. Glucuronides are formed enzymatically by the UDP-Glucuronosyltransferases which have been reported active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and the brain.
Glycoamino Acids
Glycoamino Acids
Sussex Research Laboratories Inc. has provided researchers with the most extensive selection of commercially available, high purity glycosylated amino acids (glycoamino acids). In nature, protein glycosylation, forming glycosylated proteins or glycopeptides, is a fundamental posttranslational modification process that controls protein shape, half-life and essential biological pathways ranging from protein trafficking to cell adhesion. Glycoamino acids are the basic sites of protein glycosylation, most commonly occurring at serine and threonine in the case of O-linked proteins, and at asparagine (Asn) in the case of N-linked glycoproteins.
Glycopeptides
Glycopeptides
Glycopeptides offer a unique frontier for research & development. The critical role of glycan elements on cell surface proteins and those bound to circulatory proteins is well recognized. Carbohydrates on proteins mediate a host of biological events including cell adhesion, immune system function, fertilization, cellular targeting as well as protein transport, stabilization, and half-life. Thus, the use of synthetic glycoproteins or their fragments (glycopeptides) as experimental probes for basic research and biomedical applications is growing rapidly.
Mono, Oligo & Polysaccharides
Mono, Oligo & Polysaccharides
Sussex Research Laboratories Inc. prides itself on its ability to synthesize, purify and fully characterize complex carbohydrate systems such as oligosaccharides. From blood group to GAG oligosaccharides, we are experienced in virtually all aspects of oligosaccharide synthesis. The company has an excellent infrastructure including in-house high field NMR and mass spectrometry facilities for structural validation. We use chemical, enzymatic and chemoenzymatic approaches to synthesize our oligosaccharides.
Multivalent GalNAc Ligands
Tools, Click Chemistry & Probes
Tools, Click Chemistry & Probes
As glycan features are determined on lipids and proteins within complex biological systems, it’s important to translate these findings into useful products that help advance the science in practical ways or offer new therapeutic targets to treat diseases, effect delivery of therapeutic payloads or create new biomarkers to diagnose and prognose diseases.
Reference Standards
Reference Standards
Sussex Research Laboratories Inc. synthesizes reference standards which are routinely used for quantitation and qualification of API (Active Pharmaceutical Ingredient), Metabolites and NCE’s (New Chemical Entity), as well as for Internal Standards in bioanalytical methods. These include stable isotopes (deuterated, 13C and 15N), glucuronides, metabolites & impurities.
Vitamin Standards
Vitamin Standards
These synthetic stable isotope-labelled vitamin D2, D3, E and cholesterol products, along with their hydroxy metabolites, are of the highest quality and used by researchers worldwide. These stable isotope-labelled standards are optimal for use as gold standard analytical standards and as such are trusted in the analytical protocols of global nutrition companies and bioanalytical contract research organizations on five continents.
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About Us
About Us
Sussex Research Laboratories Inc. has been diligently serving the research & development community for over 25 years and is the leading specialist in the design and synthesis of carbohydrate-based molecules for the advancement of human health.
Our Teams
Our Teams
Learn about the exceptionally qualified individuals who set Sussex Research Laboratories Inc. apart from the rest.
News
News
Explore recent news and collaborations featuring Sussex Research Laboratories Inc.
Careers
Careers
Join our dedicated team of chemists who are passionate about carbohydrate synthesis and synthetic challenges.
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Services
Services
Sussex Research Laboratories Inc. has been working in the carbohydrate field for over two decades and have applied our synthetic strategies to seemingly countless problems. We have enabled application of complex carbohydrate systems for drug discovery, drug delivery, drug targeting, carbohydrate-based vaccine development, immunotherapy, therapeutic enhancement and diagnostic/bio-analytical assay development.
Custom Synthesis
Custom Synthesis
As an established global leader in carbohydrate synthesis, we strive to develop synthetic methods that are scalable, cost-effective and enabling. We prepare a wide variety of custom glycopeptides, oligosaccharides, modified carbohydrates and many other glycosystems.
Contract Research & Development
Contract Research & Development
We are known worldwide for our contract R&D capabilities which utilize our core expertise in carbohydrate synthesis and method development.
Early Stage Drug Development
Early Stage Drug Development
We have been active in the field for many years in early stage drug development specializing in GalNAc for drug targeting, polysaccharide chemistry for vaccine development and glycans for cancer research.
Antibody Drug Conjugate (ADC)
Antibody Drug Conjugate (ADC)
Therapeutic antibodies have become the predominant class of new drugs developed in recent years. Whether it is the antigen required to screen antibodies or to produce an antibody, we have the synthetic tools to produce carbohydrate antigens and their respective carrier protein conjugates.
Analytical Services
Analytical Services
We offer analytical and bioanalytical services on a fee-for-service basis – from glycoanalysis in support of structure characterization to small molecule characterization and bioanalytical analysis in support of drug discovery and research programs.
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Products
We take great pride in our novel portfolio of carbohydrate-based and stable isotope-labeled products for the innovative modern researcher.
Product Category
Biotinylated Ligands
Carbohydrate Ligands
GalNAc Ligands
Glucuronide Metabolites
Glycoamino Acids
Glycopeptides
Mono, Oligo & Polysaccharides
Multivalent GalNAc Ligands
Reference Standards
Tools, Click Chemistry & Probes
Uncategorized
Vitamin Standards
Carbohydrate Ligands
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About Carbohydrate Ligands
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Alcohols
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Alkyne
Alkynes
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Carboxylic Acids
Enzyme Substrates
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GalNAc Ligands
GlcNAc Ligands
Maleimides
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In Stock
Product #
: PE538000
CAS #
: N/A
Glucuronic Acid Ligand: β-D-GlcA-PEG3-5(6)-Fluorescein
In Stock
Product #
: PE580000
CAS #
: N/A
Glucose Ligand: β-Glc-PEG8-Hydroxyl
Other Names
: β-Glc-PEG8-OH, (23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricosyl) β-D-glucopyranoside
Product #
: PE602000
CAS #
: N/A
Mannose-6-Phosphate Ligand: α-Man-6-phosphate-PEG3000-Acid
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In Stock
Product #
: PE631000
CAS #
: 1072903-80-0
Mannose Ligand: α-Man-PEG3-Alkyne
Other Names
: α-Man-PEG3-Propyne, Propargyl-PEG3-α-Man, 2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethyl α-D-mannopyranoside, (Dodec-11-yn-3,6,9-trioxadodecyl) α-D-mannopyranoside
In Stock
Product #
: PE631010
CAS #
: N/A
Mannose-6-Phosphate Ligand: α-Man-6-phosphate-PEG3-Alkyne
Other Names
: M6P-PEG3-Propyne, 2-{2-[2-(Prop-2-ynyloxy)ethoxy]ethoxy}ethyl mannose-6-phosphate, (Dodec-11-yn-3,6,9-trioxadodecyl) α-D-mannose-6-phosphate
Product #
: PE632000
CAS #
: 495390-54-0
Mannose Ligand: α-Man-PEG3-Acid
Other Names
: α-Man-PEG3-COOH, 2-[2-(2-Carboxyethoxy)ethoxy]ethyl α-D-mannopyranoside, (8-Carboxy-3,6-dioxaoctyl) α-D-mannopyranoside
In Stock
Product #
: PE633000
CAS #
: 353737-46-9
Mannose Ligand: α-Man-PEG3-Amine
Other Names
: α-Man-PEG3-NH
2
, 2-[2-(2-Aminoethoxy)ethoxy]ethyl α-D-mannopyranoside, (8-Amino-3,6-dioxaoctyl) α-D-mannopyranoside
In Stock
Product #
: PE634000
CAS #
: 246855-76-5
Mannose Ligand: α-Man-PEG3-Azide
Other Names
: α-Man-PEG3-N
3
, 2-[2-(2-Azidoethoxy)ethoxy]ethyl α-D-mannopyranoside, (8-Azido-3,6-dioxaoctyl) α-D-mannopyranoside
In Stock
Product #
: PE634005
CAS #
: 153252-68-7
Mannose Ligand: α-Man-PEG3-Azide (Peracetate)
Other Names
: α-Man-PEG3-N
3
(Peracetate), 2-[2-(2-Azidoethoxy)ethoxy]ethyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside, (8-Azido-3,6-dioxaoctyl) 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside
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